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The use of small worms to inhale lung cancer cells!

Amman Today

publish date 2022-03-23 09:45:33

A new study finds that small worms can be used to inhale lung cancer, such as dogs.

Researchers from Myongji University in Korea conducted laboratory experiments on the roundworm C. elegans, and found that it squirms its way into cancer cells by following the scent trail.

Based on the findings, the researchers suggest that a ‘worm on a chip’ device could provide clinicians with a non-invasive way to detect and diagnose lung cancer at an early stage.

Currently, lung cancer is diagnosed through imaging or biopsies. However, these methods often mean that tumors are not detected in their early stages.

And while previous research has shown that dogs can be trained to sniff out human cancer, unfortunately, dogs are not practical to keep in laboratories.

And in their new study, the researchers set out to understand whether nematodes — tiny nematodes measuring just 0.04 inches long — could be used to detect cancer like dogs.

Dr. Shin Sik Choi, who led the study, said: ‘Lung cancer cells produce a different set of odor molecules than normal cells. The soil-dwelling nematode, C. elegans, is known to be attracted or repelled by certain odors, so we came up with the idea that they can The use of roundworms to detect lung cancer.

The team developed a polydimethylsiloxane rubber chip, and once it was placed on a petri dish, the researchers added a droplet containing lung cancer cells at one end, and a drop containing normal lung cells at the other end.
Then the worms were placed in the central chamber and left to crawl in either direction.

After an hour, the researchers found that more worms crawled toward the droplet containing lung cancer cells than normal cells.

In a follow-up study, researchers were able to identify specific odor molecules that worms are attracted to in lung cancer cells, including a floral-scented compound called 2-ethyl-1-hexanol.

Based on preliminary tests, the researchers estimated that the “worm-on-a-chip” device in its current iteration is 70% effective in detecting cancer cells. They now hope to improve these results by using worms that have previously been exposed to cancerous cells and have developed a “memory” of specific smell molecules.

The researchers hope to extend their tests of urine, saliva and even breath from cancer patients.

They presented their findings last week at the American Chemical Society (ACS) spring meeting.

#small #worms #inhale #lung #cancer #cells

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Source : اخبار الاردن

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