Jordan News

Many scientists use the term “glucose toxicity”, and when some called it white poison, it was not an exaggeration!
Glucose is one of the types of sugars, an important and delicious basic substance and not a poison in itself, but it becomes like a slow poison if we do not deal with it well!
In fact, you can say that it is a severe warning, and you will realize its importance in the article.
As you know that diabetes is one of the most common chronic diseases, and someone in your family, relatives or friends must have it, you may see them as normal and healthy people like us, yes, but that safety may not last long unfortunately, if blood sugar is not monitored Constantly adjusting its level well, this may seem easy, but in fact it is more complicated than that!
We often notice that patients with type 2 diabetes, after they initially benefited from dieting and taking oral hypoglycemic drugs, their blood sugar level usually does not return to high despite compliance with the diet and taking the maximum drug doses! Other organs such as the eyes and kidneys are also damaged! Why might that happen?!
This is what we will explain.
Levels of fasting blood sugar (glucose) and hemoglobin (HbA1c) may be within normal limits, but blood sugar levels after meals are often abnormal, and this constant exposure to small increases in blood sugar for a prolonged period of time can have adverse effects. On pancreatic beta cells (which are the cells that secrete insulin), according to the “glucose toxicity” theory.
Thus, the term “glucose toxicity” refers to the progressive and irreversible failure of pancreatic beta cells resulting from long-term exposure to high concentrations of blood sugar.
Unfortunately, the high concentration of glucose in the blood not only affects the pancreatic beta cells but also affects many cells and tissues, so glucose toxicity is the main cause of diabetes complications, which are often noticed only several years after the onset of the disease.
In addition to causing a deficiency in insulin secretion and an increase in tissue resistance to it, it causes retinopathy, nephropathy, neuropathy, cellulitis, fungal infections of the skin, congenital and giant anomalies in the fetus, and atherosclerosis (atherosclerosis). You have to watch it early, or else you’ll be putting a time bomb in your body.
It was also found that the persistent rise of glucose in the blood causes a weakening of the function of neutrophilic leukocytes, which is an essential part of the innate immune system, and the first line of defense in the body.
But what makes us focus on pancreatic beta cells is that they are most susceptible to damage, so how?
The researchers hypothesize that chronic oxidative stress is an important mechanism of glucose toxicity, since oxidative phosphorylation, which occurs during anaerobic glucose breakdown, generates reactive Oxygen Species ROS, which may become excessive in cases of hyperglycemia. .
Because pancreatic islet cells have very poor expression of antioxidant enzymes; The pancreas is thought to be more affected than other tissues and organs by oxidative stress.
Clinically, antioxidants can be approved as an adjuvant therapy for type 2 diabetes, because there are numerous reports of elevated oxidative stress in patients with this disease, which is characterized by incomplete blood sugar control, and the resulting chronic hyperglycemia, and severe deterioration in blood glucose levels. Function of beta cells in the pancreas.
In conclusion, we recall that maintaining blood sugar control is one of the most important things that a diabetic patient should take into account. High blood sugar – although not a short-term effect – has bad consequences that appear after years and are irreversible, and adding foods containing antioxidants (such as fruits vegetables, nuts, chocolate, tea and coffee) to the diet are desirable and supportive of health.